Work

Factors affecting hematological abnormality in HIV-infected patients at Dr. Wahidin Sudirohusodo Hospital Makassar, Indonesia

Year: 2024

Type: article

Abstract: Introduction: Human immunodeficiency virus (HIV) is characterized by a progressive damage of immune system, resulting in a number of opportunistic infections and hematological abnormalities, and become more severe in late stages.Hematological abnormalities are common manifestations, with factors including CD4+ count, opportunistic infection, and HIV viral load.The aim of this study was to investigate the correlation between CD4+ count, opportunistic infection, and HIV viral load with hematological abnormality in HIV patients. Material and methods:An observational study was conducted at tertiary institution, Dr. Wahidin Sudirohusodo Hospital, Makassar, from November 2021 to February 2022.Secondary data from medi cal records of HIV-infected patients were used.Chi-square test and independent t-test were employed to determine the correlation between CD4+ count, opportunistic infection, and HIV viral load with hematological abnormality.Results: Among 83 HIV subjects, anemia was present in 47% of the cases.Leucopenia, lymphopenia, and thrombocytopenia were observed in 10.8%, 28.9%, and 9.6%, respectively.Anemia and lymphopenia significantly correlated with CD4+ count (p < 0.001) and also, anemia correlated with sexually transmitted infection as co-infection (p = 0.044).No significant correlation was found between leucopenia and thrombocytopenia with CD4+ count (p > 0.05), between anemia and lymphopenia with opportunistic infection and co-infection (p > 0.05), and between anemia, leucopenia, lymphopenia, and thrombocytopenia with viral load (p > 0.05).Conclusions: Anemia and lymphopenia significantly correlated with CD4+ count.CD4+ count monitoring is needed for early detection of hematological abnormalities in order to lower morbidity and increase quality of life.

Source: HIV & AIDS Review

DOI: 10.5114/hivar/156690