MALAYSIAN JOURNAL OF CHEMISTRY (MJChem) MJChem is double-blind peer reviewed journal published by the Malaysian Institute of Chemistry (Institut Kimia Malaysia) E-ISSN: 2550-1658 About Editor Reader Author Reviewer Register Login Vol 26 No 5 (2024): Malaysian Journal of Chemistry Date Published: 21 October 2024 Antioxidant and Antibacterial Activities of Coriander (Coriander sativum L.) Seeds Essential Oil Mazlin Mohideen*, Anis Mohd Amran, Auni Farhah Azmi and Nur Azzalia Kamaruzaman 1-9Corrosion Inhibitory Evaluation of Indole-3-Carbaldehyde 4-Methyl-3-Thiosemicarbazone on Mild Steel: Weight Loss, Langmuir Isotherm, SEM-EDX and DFT Analysis Intan Syahirah Abdul Salam, Sheikh Ahmad Izaddin Sheikh Mohd Ghazali, Siti Syaida Sirat and Nur Nadia Dzulkifli* 10-22Photocatalytic Degradation of Phenol using Copper-Doped Graphitic Carbon Nitride under Fluorescent and Sunlight Irradiation Nurul Izzah Norhisan, Siti Hajar Alias*, Nur Nazzatul Azzin Ahmad Tarmizi, Siti Nor Atika Baharin, Salman Al Faridzy Akbar, Sheikh Ahmad Izaddin Sheikh Mohd Ghazali and Hadi Nur 23-33Assessment of Organobentonite’s Adsorption Kinetics for Efficient Removal of Methylene Blue Dye from Aqueous Solutions Sami Mohammad, Mohamad Nasir Mohamad Ibrahim, Sumiyyah Sabar, Rahadian Zainul*, Ida Ayu Gede Widihati, Harits Atika Ariyanta and Anwar Iqbal* 34-45Surface and Textural Analyses for Bimetallic Nickel-Based Catalyst onto Various Support using Microwave Assisted Synthesis Salma Samidin, Azizul Hakim Lahuri, Wan Nor Roslam Wan Isahak*, Khairul Naim Ahmad, Muhammad Rahimi Yusop and Norliza Dzakaria 46-55Evaluation of Different Metal-Doped ZIF-8 Through Cyclic Voltammetry for Fuel Cell Electrode Khairul Rijal Razali, Muhammad Hafiz Nor Sham, Aishah Abdul Jalil and Juan Matmin* 56-62Studies on Phytochemical and Biological Activities of Mentha piperita (Peppermint) Anis Nadira Mahat and Rohaiza Saat* 63-71Exploring SB2OME and Metal Complexes as Antibacterial Agents: Synthesis, Characterization and Molecular Docking
Year: 2024
Type: article
Abstract: A series of new substituted dithiocarbazate, S-benzyl-β-N-2-methoxybenzoyl dithiocarbazate (SB2OME), and its metal complexes have been successfully synthesised and characterised.SB2OME was synthesised via condensation of S-benzyldithiocarbazate (SBDTC) with 2methoxybenzoyl chloride before complexing with various metal ions to yield a tridentate ONS Cu(II), Zn(II), Co(II), and Ni(II) complexes.All compounds underwent characterization via various physico-chemical analyses.Antibacterial activities of all the compounds were evaluated against Staphylococcus aureus (ATCC 25923) and Escherichia coli (ATCC 25922).ADMET prediction was utilised to assess drug-likeness.The molecular docking was used against mutant and wild-type DNA gyrase B receptor E. coli (PDB:1AJ6 and 4WUB) to evaluate whether the bioactivities of the compounds are in correlation with the mechanism of DNA supercoiling.Invitro analysis demonstrated that SB2OME and its metal complexes exhibit certain effectiveness against S. aureus and E. coli, and their potency, as measured by MIC values, is significantly inferior to that of well-established antibiotics.The ADMET prediction showed that SB2OME and its metal complexes possess favourable drug-likeness properties.From the molecular docking study, all the synthesised compounds prefer to bind with wild-type compared to the mutant DNA gyrase B. However, the absence of agreement between the binding energy and experimental results indicates that DNA gyrase B might not be the possible mechanism of action for the investigated compounds, as compared to their MIC values.Hence, this study concluded the necessity for structural modifications to enhance potency and effectiveness against pathogenic bacteria, alongside exploring additional computational methods to gain a deeper understanding of how newly synthesized compounds exert their mechanism of action.
Source: Malaysian Journal of Chemistry
Language: English
Open Access status: bronze
OpenAlex ID: W4403014591