Work

Experimental Insights into the Formation, Reactivity, and Crosstalk of Thionitrite (SNO − ) and Perthionitrite (SSNO − )

Year: 2024

Type: article

Abstract: Hydrogen sulfide (H 2 S) and nitric oxide (NO) are important gaseous biological signaling molecules that are involved in complex cellular pathways. A number of physiological processes require both H 2 S and NO, which has led to the proposal that different H 2 S/NO⋅ crosstalk species, including thionitrite (SNO − ) and perthionitrite (SSNO − ), are responsible for this observed codependence. Despite the importance of these S/N hybrid species, the reported properties and characterization, as well as the fundamental pathways of formation and subsequent reactivity, remain poorly understood. Herein we report new experimental insights into the fundamental reaction chemistry of pathways to form SNO − and SSNO − , including mechanisms for proton‐mediated interconversion. In addition, we demonstrate new modes of reactivity with other sulfur‐containing potential crosstalk species, including carbonyl sulfide (COS).

Source: Angewandte Chemie International Edition

Authors: Amanda G. Davis, Michael D. Pluth

Institution: University of Oregon

Language: English

Topic: Sulfur Compounds in Biology

Subfield: Biochemistry

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: bronze

Funders: National Science Foundation, National Institutes of Health, National Institute of General Medical Sciences, Division of Chemistry, Office of Extramural Research, National Institutes of Health

Awards: G1872854170, G2061939553, G3491647345, Molecular Recognition of Anionic Sulfur, Oxygen, and Nitrogen Species, The Development of Novel Anion Receptors for Reactive Sulfur, Oxygen, and Nitrogen Species, G755737409, NRT-URoL: Molecular Probes and Sensors for Complex Environments, G9000265596

OpenAlex ID: W4403025468

FWCI: 1.644

Cites: 43

Cited by: 13

Related to: 10