Year: 2024
Type: article
Abstract: Background Epstein–Barr virus (EBV) is a double‐stranded DNA herpesvirus and establishes life‐long infection in 95% of the world's populations. Main body EBV is critically involved in multiple diseases. Aberrant signaling pathways, immune escape, and metabolic reprogramming play essential roles in EBV‐mediated pathogenesis. However, the underlying mechanisms have not yet been fully elucidated. Here we reviewed recent advances on the epigenetic regulation of EBV pathogenesis, which may translate to potential therapeutic strategies in EBV‐associated diseases. Conclusion Growing evidence has suggested that viral infections reconstruct epigenome to modulate gene expression both in the host and the virus levels.
DOI: 10.1002/ctd2.357
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,420
Funders: Samuel Waxman Cancer Research Foundation, National Natural Science Foundation of China, Shanghai Municipal Education Commission, Shanghai Jiao Tong University, Shanghai Hospital Development Center, Shanghai Rising-Star Program, School of Medicine, Shanghai Jiao Tong University, National Key Research and Development Program of China
OpenAlex ID: W4403045900