Dual‐Responsive MnO 2 ‐Loaded Carbonaceous Nanobottle Motors Fabricated by Interfacial Superassembly for On‐The‐Fly MicroRNA Sensing
Year: 2024
Type: article
Abstract: Diverse nanomotors with advanced motion manipulation have been proposed to revolutionize the way problems in many fields are solved. However, rational and controllable synthetic methods of multifunctional nanomotor are still limited. Herein, dual‐responsive MnO 2 ‐loaded carbonaceous nanobottle motors (MnO 2 NBMs) are developed through an interfacial superassembly strategy. Asymmetric carbonaceous nanobottles are first synthesized, and the reductive carbonaceous shell induces an oxidation‐reduction reaction with KMnO 4 for in‐situ growth of MnO 2 nanosheets, which enables the nanomotor to perform either self‐diffusiophoretic or self‐thermophoretic motion in response to H 2 O 2 and near‐infrared light, respectively. Inspired by bioaffinity sensing, the nanomotors are sequentially assembled with functional nanoparticles and hairpin DNA to construct swimming functional MnO 2 NBMs (MnO 2 FNBMs) probes. The probes can move around complex samples to improve target miRNA transport and accelerate receptor‐target interaction. Coupling with the photocurrent‐signal amplification, the self‐assembly of photoelectrochemical (PEC) biosensors has been achieved for sensitive microRNA detection. Trace amounts of miRNA‐155 can be quickly detected with a wide detection range (100 fM to 100 nM). Moreover, the direct detection of microRNA in tumor cell lysates by the biosensor is demonstrated. Given the merits of automation and miniaturization, the proposed strategy provides a promising method for fast and effective self‐assembly of biosensors.
Source: Small
Authors: Enhui Ma, Ke Wang, Yineng Gou, Wenqing Luo, Hong Wang
Institution: China University of Mining and Technology
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: bronze
Awards: G403682556, G4236825976, G7096317088
OpenAlex ID: W4403046488