Work

Maternal Herpes Zoster Infection Preceding Neonatal Langerhans Cell Histiocytosis: Coincidence or Association?

Year: 2024

Type: article

Abstract: Langerhans cell histiocytosis (LCH) is a rare proliferative disorder involving bone marrow-derived antigen-presenting cells. It can present across a wide age range, from infancy to adulthood, with neonatal cases being particularly uncommon but often associated with a favorable prognosis. The factors contributing to the development of LCH remain poorly understood, though possible influences include genetic predispositions, immune dysregulation, and prenatal environmental exposures. We report a case of a female newborn diagnosed with LCH, whose mother had a history of varicella-zoster infection during pregnancy, suggesting a potential prenatal influence.

Source: Cureus

DOI: 10.7759/cureus.70702

Authors: Rahaf Alshareef, Abdulmalik Alqahtani, Shaikah Al-Aojan

Institutions: Riyadh Armed Forces Hospital, Ministry of Health

Language: English

Topic: Histiocytic Disorders and Treatments

Subfield: Physiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4403051167