Genomic analysis of an acute gastroenteritis outbreak caused by rotavirus C in Hebei, China
Year: 2024
Type: article
Study design: Observational Study
Abstract: Rotavirus group C is an important cause of sporadic cases and outbreaks of gastroenteritis worldwide. Whole-Genome sequences of human rotavirus C (RVC) in public databases are limited. We performed genome sequencing to analyze a RVC outbreak of acute gastroenteritis in China. Samples from 22 patients were screened for pathogens using RT-PCR, and six samples were positive for rotavirus. Whole-Genome sequencing analysis showed that the outbreak strain SJZ217 belongs to the G4-P[2]-I2-R2-C2-M3-A2-N2-T2-E2-H2 genotype and shares almost identical genomic sequences with Chungnam isolated in Korea. Phylogenetic analysis revealed strain SJZ217 also fell into a cluster with rotavirus C strains from Japan and Europe. Reassortment in the VP4 fragment was observed. These results helped to understand the genetic diversity and possible spread of RVC strains.
Source: Virology Journal
Authors: Kaiying Wang, Yun Wang, Lang Yang, Jinhui Li, Peihan Li, Peihan Li, Chaojie Yang, Leili Jia, Shaofu Qiu, Hongbin Song, Peng Li, Peng Li
Institution: Tianjin Centers for Disease Control and Prevention
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,190
Awards: G4994872625, G504083406, G5773670987
OpenAlex ID: W4403063054