Association between myocardial layer-specific strain and high 10-year risk of atherosclerotic cardiovascular disease in hypertension—findings from the China-PAR project study
Year: 2024
Type: article
Abstract: Objectives Myocardial layer-specific strain is a sensitive tool for detecting myocardial dysfunction. The objective of this study was to assess changes in the left ventricle (LV) function using myocardial layer-specific strain and its association with 10-year atherosclerotic cardiovascular disease risk (10Y-ASCVDR) in individuals with hypertension (HP). Methods The parameters of LV structure, including layer-specific global longitudinal strain (GLS ww , GLS endo , GLS mid , GLS epi ) and layer-specific global circumferential strain (GCS ww , GCS endo , GCS mid , GCS epi ), were analyzed by two-dimensional speckle-tracking echocardiography in 239 hypertensive patients and 124 control subjects. In addition, participants were divided into low-risk (LR) and high-risk (HR) subgroups according to 10Y-ASCVDR scores . The correlation between myocardial layer-specific strain and 10Y-ASCVDR was further analyzed by the restricted cubic spline (RCS) function. Results The values of GLS ww , GLS epi , GLS mid , and GLS endo were significantly lower in HP patients with HR than in HP patients with LR and controls ( p < 0.05). However, no significant differences in layer-specific GCS were observed between the groups ( p > 0.05). RCS analysis revealed that 10Y-ASCVDR exhibited a significant J-shaped relationship with layer-specific GLS and GCS. After adjusting for confounding factors, GLS ww ( β = 0.156, p = 0.042), GLS mid ( β = 0.161, p = 0.032), GCS endo ( β = 0.163, p = 0.024), and GCS mid ( β = −0.175, p = 0.030) were identified as independent influencing factors for high 10Y-ASCVDR. Conclusions In hypertensive patients, myocardial layer-specific strain, especially GLS, sensitively detected LV dysfunction and showed a significant J-shaped relationship with 10Y-ASCVDR. GCS mid may have a compensatory effect on myocardial impairment. LV myocardial layer-specific strain may help to understand the early compensatory mechanisms of the myocardium in hypertension.
Authors: Jianxiong Chen, Xiaohuan Yang, Xinyi Li, Lin Jin, Lingheng Wu, Mengjiao Zhang, Lianfang Du, Xianghong Luo, Zhaojun Li
Institutions: Fujian Medical University, Shanghai First People's Hospital, Nanjing Medical University, Tongji University, Hubei University, Shanghai University of Traditional Chinese Medicine, Shanghai Guanghua Hospital of Integrated Traditional Chinese and Western Medicine, Weifang Medical University, Shanghai Jiao Tong University
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,295
Award: PEDF抑制动脉外膜滋养血管稳定易损斑块的实验研究
OpenAlex ID: W4403079685