Year: 2024
Type: conference-paper
Abstract: Collagen, the main component of the extracellular matrix, and its triple helical structure provide strength and stability to connective tissues. 1 Synthetic collagen model peptides (CMPs) are useful for studying the structure and stability of natural collagen and exploring the effect of functional groups on the properties and function of collagen.Our group has shown that CMPs bearing hydrophobic moieties form fast-folding and hyperstable homotrimeric triple helices in water.2,3• In nature, most collagens consist of two or three different strands.Our lab showed that the controlled assembly of synthetic heterotrimers can be achieved through an interstrand salt bridge between (4S)aminoproline and aspartic acid.4,5 The folding rate is however slower compared to that of homotrimers.
Source: European Peptide Symposium (EPS)
Language: English
Subfield: Biomaterials
Field: Materials Science
Domain: Physical Sciences
Open Access status: bronze
OpenAlex ID: W4403085925