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An efficient strategy to bioconjugate disulfide-rich peptides via thiol-maleimide chemistry while preserving their bridging pattern

Year: 2024

Type: conference-paper

Abstract: Lingo-1[1-20]Small disulfide-constrained peptide mimicking the 3D structure of the extracellular N-terminal part of LINGO-1, a membrane protein involved in neurodegenerative diseases. ELISA assay on post-immunization serum confirmed the presence of Lingo-1[1-20]-specific IgG antibodies * Coating: Lingo-1[1-20]-GK(N 3 )

Source: European Peptide Symposium (EPS)

DOI: 10.17952/37eps.2024.p1022

Authors: Lylia Azzoug, Hervé Meudal, Karine Loth, Séverine Morisset-Lopez, Carlo Pifferi, Vincent Aucagne

Institutions: Centre National de la Recherche Scientifique, Centre de Biophysique Moléculaire

Language: English

Topic: Chemical Synthesis and Analysis

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: bronze

OpenAlex ID: W4403085941

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