Protein semi-synthetic approach to probe C-terminal hyperphosphorylation of the Alzheimer-relevant protein Tau
Year: 2024
Type: conference-paper
Abstract: Important PHF-1 phosphorylation sites S396 S400 S404➢ Microtubule-associated Tau plays an important role in Alzheimer's disease (AD) 1 .➢ PTMs play a major role in the regulation of tubulin polymerization and/or stabilization of microtubule assembly 2-4 . ➢The PHF-1 epitope (Ser396, Ser400, and Ser404) of Tau comprising three phosphorylation sites is believed to be essential in the progression of AD 5 . EPL strategy 6-8 243
Source: European Peptide Symposium (EPS)
Institutions: Leibniz-Forschungsinstitut für Molekulare Pharmakologie, Centre National de la Recherche Scientifique, Inserm, Institut Pasteur de Lille, Centre Hospitalier Universitaire de Lille, Approches épidémiologiques et moléculaires intégratives visant à améliorer la compréhension des maladies chroniques liées au vieillissement, Integrative Structural Biology, Humboldt-Universität zu Berlin
Language: English
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W4403085983