Year: 2024
Type: article
Abstract: The study explores the intricate biochemical mechanisms driving aging and their inferences for prolonged existence and to identify implicit remedial targets for interventions that promote healthier aging. A comprehensive literature investigation was conducted across different databases and search machines to identify material exploration papers, reviews, and studies concentrated on critical biochemical mechanisms driving aging. Data abstraction and synthesis were performed to organize findings into thematic sections, each devoted to a specific biochemical mechanism. The connection of these mechanisms and their relative influence on aging were investigated, and consequences for age-associated conditions and implicit strategies to enhance health span and lifetime were explored. The review highlights the pivotal function of cellular anility, genomic integrity, mitochondrial function, inflammation, genetics, epigenetic regulation, and nutrient seeing in shaping the aging process. Transcriptional processes, including RNA polymerase II extension speed and chromatin structure, are also intertwined in aging. Sirtuins, NAD, and circadian timepieces regulate lifetime and health span, while exercise and nutrition play pivotal functions in maintaining cellular health. Drugs targeting aging pathways and biomarkers for assessing aging processes show capacity. This study provides a comprehensive understanding of the molecular mechanisms underpinning aging and lifetime regulation, stressing the significance of interdisciplinary exploration in addressing the complex challenges of aging. The known biochemical mechanisms offer implicit remedial targets for interventions promoting healthier aging and extended life. Evolving trends and impending directions in longevity research are bandied, and limitations and challenges in deciphering exploration issues into practical interventions are addressed.
Authors: Abraham E. Ubhenin, Joshua Ikebuiro, Fatima A. Adamude, Mohammed A. Abdulrasak, Jibril H. Limam, Kingsley Omage
Language: English
Subfield: Aging
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W4403089817