Year: 2024
Type: conference-abstract
Abstract: Self-assembled Peptides for Biomimetic Mineralization and Enamel RepairBiomimetic mineralization strategy based on self-assembling scaffolds plays a vital role in the formation of highly mineralized organic-inorganic hybrid complexes, which possesses great potential for elucidating the mechanism of biomineralization.Herein, we have developed three self-assembled peptides including a phosphorylated protein segment (LCPS-OP), a phosphonated protein segment (LCPS-CP) and a branched amphipathic polypeptide (CAMP 15 ), which are utilized as biocompatible scaffolds to template epitaxial growth of HAP in situ on demineralized enamel surfaces, forming new remineralized enamel layers while reducing the adhesion of Streptococcus mutans.These results demonstrate the promising performance of these novel polypeptides in the regulation of biomimetic mineralization interfaces and hold great biomedical potential in the effective repair of defected enamel, as well as in the prevention of dental caries regeneration.
Source: European Peptide Symposium (EPS)
Authors: Yue Li, Rong Chang, Yang-Jia Liu, Feng Chen, Yong-Xiang Chen
Language: English
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: bronze
OpenAlex ID: W4403099864