Work

Conserved mechanism of Xrn1 regulation by glycolytic flux and protein aggregation

Year: 2024

Type: article

Abstract: , the human orthologue of Xrn1 mirrors its yeast counterpart, i.e., it segregates to the eisosome under conditions of halted glycolysis. Our results not only advance our understanding of Xrn1 regulation but also indicate that this regulatory principle is conserved from yeast to humans.

Source: Heliyon

DOI: 10.1016/j.heliyon.2024.e38786

Authors: Satyendra Mondal, Jakub Zahumensky, Petra Vesela, Jan Malinsky

Institutions: Czech Academy of Sciences, Czech Academy of Sciences, Institute of Experimental Medicine

Language: English

Topic: RNA Research and Splicing

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,100