Work

Crohn's disease-associated keratopathy: A case report

Year: 2024

Type: article

Abstract: Purpose: This study reports a case of Crohn's disease-associated keratopathy that progressed with disease activity. Observations: A 29-year-old man diagnosed with Crohn's disease and receiving systemic adalimumab therapy, presented with an irregular epithelial surface, superior corneal opacity, subepithelial infiltration, pannus with new vessel ingrowth, and punctate epithelial erosions in both corneas. Changes in ophthalmological findings were checked during regular outpatient follow-ups. We also compared the stool calprotectin values obtained at a gastrointestinal clinic during the course of keratopathy. By analyzing the trend of fecal calprotectin levels in this patient, we found that keratopathy worsened as fecal calprotectin levels increased. Corneal neovascularization and infiltration improved as the fecal calprotectin levels decreased. Conclusions and importance: The mechanism of Crohn's disease-associated keratopathy has not been identified but appears to be related to the autoimmune mechanism of Crohn's disease. Managing Crohn's activity by referring to the gastroenterology department should be considered to relieve Crohn's disease-associated keratopathy.

Source: American Journal of Ophthalmology Case Reports

DOI: 10.1016/j.ajoc.2024.102186

Authors: Ji Ho Kim, Yeo Kyoung Won, Tae-young Chung, Dong Hui Lim

Institutions: Samsung Medical Center, Sungkyunkwan University

Language: English

Topic: Ocular Diseases and Behçet’s Syndrome

Subfield: Ophthalmology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,340