Work

Clostridioides difficile toxin B suppresses human neutrophil migration

Year: 2024

Type: article

Abstract: We investigated the effects of Clostridioides difficile toxin B (TcdB), a major virulence factor in C. difficile infection (CDI), on human neutrophils. TcdB inhibits neutrophil migration via loss of polarity of F-actin polymerization in response to interleukin-8. TcdB facilitates CDI by allowing C. difficile to avert the host immune system.

Source: Anaerobe

DOI: 10.1016/j.anaerobe.2024.102916

Authors: Yoshitaka Kimura, Nami Hatayama, Yoshinori Sato, Yusuke Yoshino

Institution: Teikyo University

Language: English

Topic: Clostridium difficile and Clostridium perfringens research

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,200