Work

Ethnic-specific oral glucose tolerance (OGTT) phenotypes in women with hyperglycemia in pregnancy

Year: 2024

Type: article

Abstract: INTRODUCTION: Ethnic differences associated with oral glucose tolerance test (OGTT) phenotypes is less studied in Southeast Asian ethnicities, especially in women with hyperglycemia in pregnancy (HIP). RESEARCH DESIGN AND METHODS: We retrospectively examined 3027 women at KK Women's and Children's Hospital in 2019. Of these, 508 (16.8%) women were diagnosed with HIP using the IADPSG (International Association of Diabetes and Pregnancy Study Groups) criteria at 24-28 weeks. OGTT phenotypes were classified into four mutually exclusive groups based on abnormal plasma glucose at (1) 0 hour only; (2) 1 hour only; (3) 2 hour only; (4) ≥2 timepoints (reference). Multinomial logistic regression was used to examine the association between ethnicity and OGTT phenotypes, adjusting for maternal age, parity, and first-trimester body mass index. RESULTS: Overall HIP prevalence was 16.8%, highest among Indians (20.5%), then Chinese (18.3%) and Malays (14.2%). Indians (relative risk ratio (RRR) 3.05) and Chinese (RRR 2.33) were at higher risk of displaying a fasting-only phenotype compared with Malays. Chinese were at increased risk of displaying a 2-hour postprandial phenotype with an RRR of 2.88 as compared with Malays. CONCLUSIONS: Unique OGTT phenotypes exist across ethnic groups among women who developed HIP in a multi-ethnic Asian population.

Source: BMJ Open Diabetes Research & Care

DOI: 10.1136/bmjdrc-2024-004331

Authors: Yu Bin Tan, Phaik Ling Quah, Kok Hian Tan

Institutions: Duke-NUS Medical School, KK Women's and Children's Hospital

Language: English

Topic: Gestational Diabetes Research and Management

Subfield: Obstetrics and Gynecology

Field: Medicine

Domain: Health Sciences

SDGs: Good health and well-being, Reduced inequalities

Open Access status: gold

Estimated APC paid: $3,000