Comparative analysis of clinical profile, laboratory profile and outcome in COVID-19 patients with and without hypothyroidism
Year: 2024
Type: article
Study design: Observational Study
Abstract: Objectives: Previous studies suggest that patients' thyroid status might directly impact the course of Coronavirus disease 2019 (COVID-19). The objective of the study was to determine the clinical profile of COVID-19 patients with hypothyroidism and compare it with that of COVID-19 patients without hypothyroidism. Design: Retrospective observational study. Setting: The study was conducted in a tertiary healthcare centre in Tamil Nadu between May and June 2021. Participants: The study included 117 patients admitted with hypothyroidism and COVID-19 as well as 117 age and Gender matched COVID-19 patients without hypothyroidism. Main outcome measures: Data regarding the demography, comorbidities, presenting symptoms, method of diagnosis of COVID-19, computed tomography (CT) severity score, Interleukin 6 (IL-6), D-dimer, oxygen requirement, number of days in hospital and outcome were collected for both groups. Data analysis was conducted, and p<0.05 was considered statistically significant. Results: Requirement, death, D-dimer, IL-6, number of days admitted as well as CT-severity did not show any statistically significant differences (p>0.05) between both groups. The outcomes also showed that both groups reported four mortalities. Conclusions: The results of the study help conclude that the hypothyroidism status of a COVID-19 patient is not associated with higher severity of clinical symptoms, deranged laboratory values as well as mortality. Funding: None declared.
Source: Ghana Medical Journal
DOI: 10.4314/gmj.v58i3.3
Authors: Sindhu Malini B, Yoganathan Chidambaram, Clement Jenil Dhas C P, Navinkumar B K, Sujith Kumar S
Institution: PSG Institute of Medical Sciences & Research
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4403130818