Year: 2024
Type: article
Study design: Observational Study
Abstract: Thalamocortical connectivity is associated with cognitive and affective processing. The role of thalamocortical connectivity in the pathomechanism of treatment-resistant depression (TRD) remains unclear. This study included 48 patients with TRD and 48 healthy individuals. We investigated thalamocortical connectivity by performing resting-state functional MRI with the bilateral thalamus as the seed. In addition, patients with TRD were evaluated using the Montgomery-Åsberg Depression Rating Scale (MADRS). Compared with the healthy individuals, the patients with TRD exhibited increased functional connectivity (FC) of the thalamus with the insula and superior temporal cortex and reduced the FC of the thalamus with the anterior paracingulate cortex and cerebellum crus II. Our study may support the crucial role of thalamocortical dysconnectivity in the TRD pathomechanism. However, the small sample size may limit the statistical power. A future study with a large sample size of patients with TRD would be required to validate our findings.
Source: Journal of Neuroscience Research
DOI: 10.1002/jnr.25388
Language: English
Subfield: Cognitive Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $4,840
Funders: National Science and Technology Council, Academia Sinica, Ministry of Science and Technology, Taiwan, University System of Taiwan, National Taiwan University, Yen Tjing Ling Medical Foundation, Tri-Service General Hospital, Taipei Veterans General Hospital, Kaohsiung Veterans General Hospital, National Science and Technology Council
Awards: G1220594979, G1259558558, G1292966817, G1454187482, G1743868987, G1974135887, G2055016603, G2191060952, G2205640134, G2349401661, G2521928599, G2530793813, G262263919, G265016787, G2826141355, G2889430041, G3108854269, Low-Dose Ketamine Infusion among Adolescents with Treatment-Resistant Depression: a Randomized, Double-Blind Placebo-Control Study, G3758813513, G4427410683, G449856906, G4567487053, G4942875564, G5012695417, G5072617215, Modulation of the Antidepressant and Antisuicidal Efficacy of Low-Dose Ketamine Infusion via the Mtorc1 Modulator, Rapamycin: a Double-Blind, Randomized, Placebo Controlled Trial Combined with the Neuropsychological and Functional Connectivity Mri Study., Anti-Inflammation Treatment of Mood Disorders and Deep Learning Prediction Model, G5504656684, Emotional Dysregulation as a Transdiagnostic Clinical Domain between Adolescent Adhd and Major Affective Disorders: a Prospective Neuroimaging and Neuropsychological Study, Low-Dose Ketamine Infusion among Adolescents with Treatment-Resistant Depression: a Randomized, Double-Blind Placebo-Control Study, G7489393043, Low-Dose Ketamine Infusion among Adolescents with Treatment-Resistant Depression: a Randomized, Double-Blind Placebo-Control Study., G8821328323
OpenAlex ID: W4403145330