Effect of an acute session of intermittent exercise on trimethylamine N-oxide (TMAO) production following choline ingestion
Year: 2024
Type: article
Abstract: INTRODUCTION: Trimethylamine N-oxide (TMAO) is a gut bacteria-dependent metabolite associated with poor cardiovascular health. Exercise is a known cardioprotective activity but the impact of an acute bout of exercise on TMAO production is unknown. OBJECTIVES/METHODS: This study assessed choline-derived production of TMAO following a single bout of intermittent exercise in a young, healthy cohort. RESULTS: Choline supplemented after either exercise or a time-matched resting period demonstrated a similar increase in circulating TMAO across an 8-hour period. CONCLUSION: This suggests that a single bout of intermittent exercise does not alter gut microbial metabolic behaviour and thus does not provide additional cardioprotective benefits related to blood levels of TMAO.
Source: Metabolomics
Authors: Marilyn L.Y. Ong, Christopher G. Green, Samantha N. Rowland, Katie Rider, Harry Sutcliffe, Mark P. Funnell, Andrea Salzano, Liam M. Heaney
Language: English
Topic: Gut microbiota and health
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $3,690
OpenAlex ID: W4403148204