Development and validation of machine learning models for intraoperative blood transfusion prediction in severe lumbar disc herniation
Year: 2024
Type: article
Study design: Observational Study
Abstract: Lumbar disc herniation (LDH) is a common cause of lower back pain and sciatica, and posterior lumbar interbody fusion (PLIF) is always employed. This multicenter retrospective study investigates predicting intraoperative blood transfusion for LDH patients undergoing PLIF in China. The research includes 6,241 patients from 22 medical centers and employs 8 feature selection methods and 10 machine learning models, including an integrated stacking model. The optimal predictive model was selected based on the receiver operating characteristic area under the curve, clinical applicability, and computational efficiency. Among the evaluated combinations, the simulated annealing support vector machine recursive + stacking model achieved the highest performance with an area under the curve of 0.884, supported by robust calibration and decision curve analyses. A publicly accessible web calculator was developed to assist clinicians in decision-making. This work significantly enhances intraoperative transfusion predictions, providing valuable tools for improving patient management.
Source: iScience
Authors: Qiang Liu, An-Tian Chen, Runmin Li, Liang Yan, Xubin Quan, Xiaozhu Liu, Yang Zhang, Tianyu Xiang, Yingang Zhang, Anfa Chen, Hao Jiang, Xuewen Hou, Qizhong Xu, Weiheng He, Liang Chen, Xin Zhou, Qiang Zhang, Wei Huang, Haopeng Luan, Xinghua Song, Xiaolin Yu, Xiangdong Xi, Kai Wang, Shi-Nan Wu, Wencai Liu, Yusi Zhang, Jialiang Zheng, Haizhen Ding, Chan Xu, Chengliang Yin, Zhaohui Hu, Baicheng Qiu, Wenle Li
Institutions: Xian Yang Central Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Fu Wai Hospital, State Key Laboratory of Cardiovascular Disease, The University of Texas at Austin, Xi'an Honghui Hospital, Xi'an Jiaotong University, Guangxi Medical University, Capital Medical University, Second Affiliated Hospital of Chongqing Medical University, Beijing Shijitan Hospital, First Affiliated Hospital of Xi'an Jiaotong University, First Hospital of Xi'an, Chongqing Medical University, Second Military Medical University, Shanghai Changzheng Hospital, Guangdong Medical College, Shenzhen University, Shenzhen Second People's Hospital, Ningxia Hui Autonomous Region Peoples Hospital, Hubei Provincial Hospital of Traditional Chinese Medicine, Shanxi Medical University, Shanxi Academy of Medical Sciences, Xian Central Hospital, South China University of Technology, Xinjiang Medical University, Sixth Affiliated Hospital of Xinjiang Medical University, Affiliated Hospital of Guizhou Medical University, Second Affiliated Hospital of Xuzhou Medical College, Xiamen University, Shanghai Jiao Tong University, Shanghai Sixth People's Hospital, State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, Macau University of Science and Technology
Language: English
Subfield: Health Information Management
Field: Health Professions
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,150
OpenAlex ID: W4403157348