Comparable results 5 years after one anastomosis gastric bypass compared to Roux-en-Y gastric bypass: a propensity-score matched analysis
Year: 2024
Type: article
Study design: Observational Study
Abstract: BACKGROUND: Previous studies comparing one anastomosis gastric bypass (OAGB) and Roux-en-Y gastric bypass (RYGB) are often limited by retrospective designs, or in randomized controlled trials, by small sample sizes or limited follow-up durations. OBJECTIVES: This study aims to compare OAGB and RYGB during 5years of follow-up in terms of weight loss, remission of comorbidities, and complications. SETTING: This longitudinal prospective study includes all patients who underwent a primary OAGB or RYGB between 2015 and 2016 in the Netherlands, utilizing data from the nationwide registry, Dutch Audit for Treatment of Obesity. METHODS: A 1:1 propensity-score matched (PSM) comparison between patients with OAGB and RYGB. RESULTS: After 1:1 PSM, 2 nearly identical cohorts of 860 patients were obtained. OAGB was associated with more intraoperative complications (2.0% versus .6%; P = .031). Conversely, RYGB had a higher rate of short-term complications (7.6% versus 3.8%; P < .001). Five-year data were available from 40.7% of the patients with OAGB and 34.9% with RYGB. No significant differences were observed in percentage total weight loss after 5years (30.0% after OAGB and 28.8% after RYGB; P = .099). The total remission rate of diabetes mellitus was 60.5% for OAGB and 69.4% for RYGB (P = .656). However, OAGB resulted in a significantly higher remission rate of hypertension compared to RYGB (60.2% versus 45.5%; P = .015). CONCLUSIONS: OAGB and RYGB yield comparable weight loss outcomes. However, OAGB had more intraoperative complications, while RYGB had more short-term complications. Both procedures show similar efficacy in diabetes mellitus remission, but OAGB is more effective in achieving hypertension remission.
Authors: Lindsy van der Laan, Dionne Sizoo, André P. van Beek, Marloes Emous, G.J.D. van Acker, J. Apers, S.C. Bruin, F.F.E. Bruinsma, S.M.M. de Castro, S.L. Damen, I.F. Faneyte, J.W.M. Greve, G. van ’t Hof, F.H.W. Jonker, R.A. Klaassen, E.A.G.L. Lagae, B.S. Langenhoff, R.S.L. Liem, A.A.P.M. Luijten, S.W. Nienhuijs, R.M. Smeenk, S.J.M. Smeets, W. Vening, M. Takkenberg, E. de Witte
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $3,400
Funder: Vlaamse regering
OpenAlex ID: W4403157622