Work

Non‐clinical safety evaluation of Yongdamsagan‐tang water extract: A 13‐week subchronic oral toxicity study in Sprague Dawley rats

Year: 2024

Type: article

Abstract: Despite the continued clinical application of traditional herbal medicines, scientific evidence such as toxicological safety profile of Yongdamsagan-tang water extract (YSTW) has not yet been established. The purpose of this study was to investigate the potential toxicity profile of YSTW following a 13-week repeated oral administration at various concentrations to Sprague Dawley rats. YSTW was administered orally to rats once daily at doses of 0, 1000, 2000, and 5000 mg/kg bw/day for 13 weeks. During the experimental period, there were no significant toxicological changes related to YSTW treatment. These results indicate that the administration of YSTW for 13 weeks in the rat resulted in no signs of toxicity at up to 5000 mg/kg bw/day, which was considered the no-observed-adverse-effect level.

Source: Journal of Applied Toxicology

DOI: 10.1002/jat.4703

Authors: Woo‐Young Jeon, Chang‐Seob Seo, Hyekyung Ha, Hyeun‐Kyoo Shin, Jae‐Woo Cho, Mee‐Young Lee

Institutions: Korea Institute of Oriental Medicine, Korea Institute of Toxicology

Language: English

Topic: Phytochemistry Medicinal Plant Applications

Subfield: Plant Science

Field: Agricultural and Biological Sciences

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,430