Sulfone as traceless activating group: Divergent synthesis of α-fluoroamides with C–F quaternary stereocenters
Year: 2024
Type: article
Abstract: A novel approach to α -fluoroamides bearing a C–F quaternary stereocenter is reported herein. With sulfone installed as the activating group, an alkyl group as well as a fluorine atom was introduced successively under mild conditions. Subsequently, heterolytic fission of the C–S bond occurred smoothly under photoredox conditions to afford a tertiary radical, which then engaged in varied intramolecular cyclizations depending on substrate structure and condition applied, rendering sulfone an overall traceless activating group.
Source: Green Synthesis and Catalysis
Authors: Jieqing Wu, Liying Fu, Renyi Diao, Longjun Nie, Chi Zhang, Yufeng Li, Chao Feng
Language: English
Subfield: Pharmaceutical Science
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W4403158922