Ecotoxicological and metabolomic investigation of chronic exposure of Daphnia magna (Straus, 1820) to yttrium environmental concentrations
Year: 2024
Type: article
Abstract: ) value for mortality endpoint and simulating the environmental Y level in aquatic systems. Results from the 21-day two-factor experiment combining microcrustacean survival, growth and reproduction bioassays and targeted gas chromatography-mass spectrometry (GC-MS) metabolomics indicated significant adverse effects of chronic exposure to Y on D. magna. Daphnids exposed to Y exhibited a significantly lower survival at day 21, delayed the maturity stage, including their first breeding, and decreased clutch size. On the side of metabolomics, a clear and general increase over time of both the number and the level of detected metabolites in the hydroalcoholic extracts of the whole organisms was observed. However, emerging from this broad temporal pattern, several bioactive metabolites were identified (e.g., 2,4-di‑tert‑butylphenol, itaconic acid, 3-hydroxybutyric acid, and trehalose) whose levels in extracts are linked to the presence of Y. These results emphasize the necessity of considering low-dose, long-term exposure scenarios in environmental risk assessments of rare earth elements (REEs), which have often been overlooked in favour of higher concentration studies.
Source: Aquatic Toxicology
Institution: University of Naples Federico II
Language: English
Subfield: Health, Toxicology and Mutagenesis
Field: Environmental Science
Domain: Physical Sciences
Open Access status: hybrid
Estimated APC paid: $3,460
OpenAlex ID: W4403159263