Overcoming the Blood–Brain Barrier: Multifunctional Nanomaterial‐Based Strategies for Targeted Drug Delivery in Neurological Disorders
Year: 2024
Type: article
Abstract: The development of effective therapies for neurological disorders is a growing area of research due to the increasing prevalence of these conditions. Some neurological disorders that are prevalent and remain difficult to treat are glioma, neurodegenerative disease, ischemic stroke, and traumatic brain injury. Subsequently, the therapeutic efficacy of small molecules, proteins, and oligonucleotides remains a challenge due to the presence of the blood-brain barrier (BBB), a highly selective semipermeable membrane. To this end, multifunctional nanomaterials have emerged as promising vehicles for targeted drug delivery to the brain, due to their ability to transport therapeutics across the BBB selectively. The design of advanced nanomaterial-based drug delivery systems capable of overcoming the BBB is influenced by many factors, such as fabrication technique and surface modification. This review explores the diverse range of nanomaterials, including polymer, lipid, gold, magnetic, and carbon-based nanostructures, capable of effectively passing the BBB. These materials cross the BBB via a variety of established transport mechanisms for targeted delivery of therapeutics to the brain. Moreover, the structure and function of the BBB are highlighted and the potential for nanotechnology to aid the treatment of neurological disorders based on their ability to undergo transcytosis into the brain is highlighted.
Source: Small Science
Language: English
Subfield: Biomaterials
Field: Materials Science
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $5,770
Funders: National Science Foundation, Foundation for the National Institutes of Health, Alzheimer's Association, New Jersey Commission on Spinal Cord Research, National Institutes of Health, National Heart, Lung, and Blood Institute, National Institute of General Medical Sciences, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Division of Chemical, Bioengineering, Environmental, and Transport Systems, Congressionally Directed Medical Research Programs
Awards: G1087340658, G1699319024, G1853166281, A Bio-Inspired Artificial Transcription Factor for Regeneration of Functional Hair Cells, A Bioinspired Nonviral Gene Therapy to Enhance TFEB-mediated Tau Clearance, Nanoparticle-based synthetic transcription factor to induce stem cell myogenesis, G2720384007, G2957155488, Real-Time Sensing of Neurotransmitters From Stem Cell-derived Neural Interface Using Hybrid Graphene-Nanostructures, G3736147419, G3748729055, A Bio-Inspired Artificial Transcription Factor for Regeneration of Functional Hair Cells, Rutgers Optimizes Innovation (ROI) Program, G486154502, G5044829552, G5242973955, G5432078118, Injectable Hybrid SMART spheroids to enhance stem cell therapy for CNS injuries, G6025746230, G6241112548, G7392267819, G8140293634, G9000003393, G9000045381, G9000066674, G9000098726, G9000208159, G9000283370
OpenAlex ID: W4403162344