Proof of concept validation of bioresorbable optical fibers for diffuse correlation spectroscopy

Year: 2024

Type: article

Abstract: Optical quality bioresorbable materials have been gaining interest in recent years for various interstitial biomedical/medical application. An example of this is when the implant gradually dissolves in the body, providing physiological information over extended periods of time, hence reducing the need for revision surgeries. This study reports for the first time the in-house fabrication of single mode (at 785 nm) calcium phosphate glass (CPG) based bioresorbable optical fibers and investigates their suitability for microvascular blood flow monitoring using diffuse correlation spectroscopy (DCS). Ex vivo experiments in liquid phantom and non-invasive in vivo experiments on the human forearm muscle were conducted using multimode and single mode CPG bioresorbable optical fibers. The retrieved flow index from the correlation curves acquired using CPG fibers was in good agreement with that obtained using standard silica (Si) fibers, both ex vivo and in vivo. The results demonstrate the potential of CPG optical fibers for further exploration.

Source: Biomedical Optics Express

DOI: 10.1364/boe.540137

Authors: Jawad T. Pandayil, Nadia G. Boetti, Davide Janner, Turgut Durduran, Lorenzo Cortese

Institutions: Politecnico di Torino, LINKS Foundation, Institució Catalana de Recerca i Estudis Avançats, Institute of Photonic Sciences

Language: English

Topic: Optical Imaging and Spectroscopy Techniques

Subfield: Radiology, Nuclear Medicine and Imaging

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,913

Funders: Fundación Cellex, Centres de Recerca de Catalunya, Laserlab-Europe, European Commission, Generalitat de Catalunya, National Institutes of Health, Horizon 2020 Framework Programme, Agència de Gestió d'Ajuts Universitaris i de Recerca, Instituto de Salud Carlos III, Agencia Estatal de Investigación, HORIZON EUROPE Marie Sklodowska-Curie Actions

OpenAlex ID: W4403171615