Work

Anatomical and physiological aspects of the mutual influence of circulatory hypoxia of the myometrium and non-progressive labour

Year: 2024

Type: article

Abstract: Non-progressive labour occurs in almost 10% of deliveries and is a main reason for unplanned cesarean sections and operative vaginal births using obstetric forceps or vacuum extraction. This article describes the morphological transformation of the myometrium and uterine blood vessels that occurs during pregnancy. It is shown that the myometrium inevitably experiences hypoxia at the microstructural level during each normal or pathological labour. We analyzed recent studies of the mutual influence of myometrial hypoxia and labour dystocia. Experimental and clinical studies showed relationship between the pH values and lactate levels determined in the myometrium on its contractility. Further research is justified, including the study of the pH and lactate values in amniotic fluid in patients with non-progressive labor. Finally, that will allow for clarifying the conditions and timing of labour stimulation with oxytocin and identifying a group of patients for whom oxytocin administration is contraindicated or hopeless.

Source: Journal of obstetrics and women s diseases

DOI: 10.17816/jowd623763

Authors: Dmitry S. Sudakov, Igor P. Nikolaenkov, Yulia R. Dymarskaya, Anna A. Kuznetsova

Institutions: Research Institute of Obstetrics and Gynecology named after D.O. Ott, North-Western State Medical University named after I.I. Mechnikov

Language: English

Topic: Maternal and Perinatal Health Interventions

Subfield: Obstetrics and Gynecology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W4403176819

FWCI: 0.482

Cites: 86

Cited by: 1

Related to: 10