Work

Continuous flow synthesis of N , N -dimethyltryptamine (DMT) analogues with therapeutic potential

Year: 2024

Type: article

Abstract: -dimethyltryptamine (DMT) and several of its analogues using a Fischer indole reaction, along with a larger gram scale synthesis (4.75 g) of the model compound. These products could then be quickly transformed into their respective fumarate salts, making them easier to handle and stable for long time storage using a straightforward batch procedure. Additionally, the commercially available drug rizatriptan benzoate could be synthesised with high purity using this setup. The presented method employs relatively green solvents both for the synthesis and purification of the target products.

Source: RSC Medicinal Chemistry

DOI: 10.1039/d4md00562g

Authors: Andreas Simoens, Andreas Dejaegere, Marthe Vandevelde, Christian V. Stevens

Institution: Ghent University

Language: English

Topic: Innovative Microfluidic and Catalytic Techniques Innovation

Subfield: Biomedical Engineering

Field: Engineering

Domain: Physical Sciences

Open Access status: hybrid

OpenAlex ID: W4403180565

FWCI: 0.32

Cites: 40

Cited by: 3

Related to: 10