Work

Troubling bonds: lipid unsaturation promotes selenium dependency and sensitivity to ferroptosis

Year: 2024

Type: article

Abstract: Cancer cells exhibit a remarkable ability to orchestrate metabolic adaptations to survive and proliferate. Such metabolic adaptations, including carbohydrates, amino acids and lipid metabolism, have been shown to also contribute to the pathological cascade during cancer progression and therapy resistance. Importantly, these adaptations provide a rational for targeted therapies inducing selective cell death. Recently, two studies by Lorito et al (Lorito et al, 2024) and Ackermann et al (Ackermann et al, 2024) published in EMBO Molecular Medicine reported examples of alterations in lipid metabolism that can promote targetable vulnerabilities for tumors with poor prognosis. J. P. Friedmann-Angeli and A. F. dos Santos highlight two complementary studies recently published in EMBO Mol. Med. reporting examples of alterations in lipid metabolism that can promote targetable vulnerabilities for breast tumors with poor prognosis.

Source: EMBO Molecular Medicine

DOI: 10.1038/s44321-024-00150-x

Authors: Ancély Ferreira dos Santos, José Pedro Friedmann-Angeli

Institution: University of Würzburg

Language: English

Topic: Ferroptosis and cancer prognosis

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $6,890