Work

Antiepileptic drugs, folate one‐carbon metabolism, genetics, and epigenetics: Congenital, developmental, and neuropsychological risks and antiepileptic action

Year: 2024

Type: article

Abstract: F I G U R E 1Relationships between the folate cycle, vitamin B12, nucleotide synthesis, and the methylation cycle.Folic acid is a synthetic unnatural form of the vitamin that first must be reduced by dihydrofolate reductase to the natural tetrahydrofolate form to enter the folate cycle.5-Methyltetrahydrofolate (5MTHF) is the active transport form into the nervous system.The methyl group of 5MTHF enters the methylation cycle and is ultimately utilized in numerous genomic and nongenomic methylation reactions.

Source: Epilepsia

DOI: 10.1111/epi.18120

Author: Edward H. Reynolds

Institution: King's College London

Language: English

Topic: Pharmacological Effects and Toxicity Studies

Subfield: Pediatrics, Perinatology and Child Health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,150