Acyl CoA binding protein (ACBP): an autophagy checkpoint that can be targeted for improving cancer immunosurveillance
Year: 2024
Type: article
Abstract: Acyl CoA binding protein (ACBP) encoded by DBI is a tissue hormone that limits autophagy in multiple cell types, hence acting as an extracellular autophagy checkpoint. We recently reported in Molecular Cancer that monoclonal antibodies neutralizing ACBP improve immunosurveillance of breast and lung carcinomas. Moreover, ACBP neutralization improves the outcome of neoadjuvant chemoimmunotherapy with PD-1 blockade in preclinical models.
Source: OncoImmunology
Authors: Léa Montégut, Isabelle Martins, Guido Kroemer
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,913
Funders: Association pour la Recherche sur le Cancer, Seerave Foundation, Equipex, European Commission, Agence Nationale de la Recherche, Institut National de la Santé et de la Recherche Médicale, Fondation pour la Recherche Médicale, Ligue Contre le Cancer, Institut Universitaire de France, Institut National Du Cancer, Direction Générale de l’offre de Soins, Ministère des Solidarités et de la Santé, Université de Paris, HORIZON EUROPE Framework Programme, European Research Council, Labex Immuno-Oncology, HORIZON EUROPE European Research Council
Awards: G1056382719, G1190173965, Development of “smart” amplifiers of reactive oxygen species specific to aberrant polymorphonuclear neutrophils for treatment of inflammatory and autoimmune diseases, cancer and myeloablation., G1540355574, Next-generation phenotypic screening for oncological applications, G1941370527, G1963894250, Lung cancer prevention and interception, Biomarkers affecting the transition from cardiovascular disease to lung cancer: towards stratified interception., Gut OncoMicrobiome Signatures (GOMS) associated with cancer incidence, prognosis and prediction of treatment response., G3231222199, G330243840, G434337789, G461710914, G4656594441, G4707887143, Immunogenic cell death (ICD) in the cancer-immune dialogue, Energizing the failing heart, Metabolic and Autophagic Control by Acyl CoA Binding Protein (ACBP/DBI), G7041469554, G7101784390, G7255431040, G7466508714, G7562053067, G82931992, G8471630636, Université de Paris, G8809306651, The RUSH (retention using selective hooks) system: a chemical-genetic system for the in vivo manipulation of intercellular communication
OpenAlex ID: W4403189538