The impact of the physicochemical properties of calcium phosphate ceramics on biocompatibility and osteogenic differentiation of mesenchymal stem cells
Year: 2024
Type: article
Abstract: OBJECTIVE: In this study we have focused on biocompatibility and osteoinductive capacity analysis of self-manufactured single-phase (HAP) and two-phase (HAP and β-ТСР) bioactive ceramics with various chemical modifications (Fig. 1). RESULTS: , accompanied by an enhancement in adsorption activity. This modification also resulted in an increase in micro- and macroporosity, along with a rise in the open porosity. Adipose-derived mesenchymal stromal cells demonstrated excellent cell adhesion and survival when cultured with these ceramics. Calcium phosphate ceramics (H-500, HT-500, and HT-1 series) stimulated alkaline phosphatase expression, promoted calcium deposition, and enhanced osteopontin expression in ADSCs, independently inducing osteogenesis without additional osteogenic stimuli. These findings underscore the promising potential of HAP-based bioceramics for bone regeneration/reconstruction.
Source: BMC Research Notes
Institutions: National Academy of Sciences of Ukraine, Universitätsklinikum Tübingen, Institute of Molecular Biology and Genetics, University of Tübingen, Frantsevich Institute for Problems in Materials Science, Instytut Biologii Doświadczalnej im. Marcelego Nenckiego, Polish Academy of Sciences, Center for Regenerative Therapies Dresden, Technische Universität Dresden
Language: English
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $1,790
Award: G7921069323
OpenAlex ID: W4403189971