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The Trajectory of Antibody Responses One Year Following SARS-CoV-2 Infection among Indigenous Individuals in the Southwest United States

Year: 2024
Type: article
Study design: Observational Study
Abstract: SARS-CoV-2 antibody kinetics based on immunologic history is not fully understood. We analyzed anti-spike and anti-nucleocapsid antibody responses following acute infection in a cohort of Indigenous persons. The models of peak concentrations and decay rates estimated that one year after infection, participants would serorevert for anti-nucleocapsid antibodies and remain seropositive for anti-spike antibodies. The peak anti-spike concentrations were higher for individuals vaccinated prior to infection, but the decay rates were similar across immunologic status groups. Children had significantly lower peak anti-spike concentrations than adults. This study affirms the importance of continued vaccination to maintain high levels of immunity in the face of waning immunity.
Source: Viruses
DOI: 10.3390/v16101573
Authors: Claire P. Smith, Rachel M. Hartman, Alexa M. Kugler, Verlena Little, Owen R. Baker, Tarayn A. Fairlie, Reinaldo E. Fernandez, Melissa B. Hagen, Elvira Honie, Oliver Laeyendecker, Claire M. Midgley, Dennie Parker, Marqia Sandoval, Saki Takahashi, Laura L. Hammitt, Catherine G. Sutcliffe
Institutions: Johns Hopkins University, Johns Hopkins Medicine, Centers for Disease Control and Prevention, National Center for Immunization and Respiratory Diseases, National Institutes of Health, National Institute of Allergy and Infectious Diseases
Language: English
Field: Medicine
Open Access status: gold
Estimated APC paid: $2,955
OpenAlex ID: W4403194403
FWCI:
Cites: 39
Cited by:
Related to: 10