Work

Therapeutic Performance of Needle Injection Versus Needle‐Free Jet Injector System for Polynucleotide Filler in Skin Rejuvenation

Year: 2024

Type: article

Abstract: BACKGROUND: Polynucleotide (PN) filler often causes pain and can lead to delivery inaccuracies when applied via intradermal injection using a traditional needle. AIMS: To evaluate the efficacy of treatment and the pain during the procedure using conventional needle injection versus a needle-free jet system for intradermal PN filler application. METHODS: In this split-face clinical trial, 10 Korean subjects were enrolled. Each subject received an intradermal injection of PN filler on one side of the face and a needle-free jet injection using CureJet on the other side. Assessments included global and 3D skin imaging at each visit. Pain intensity was evaluated using visual analogue scale (VAS) scores during the injection. Additionally, patient satisfaction and adverse events were documented. RESULTS: Findings revealed that Global Aesthetic Improvement Scale scores and patient satisfaction were significantly higher with the CureJet compared to the needle injection method. VAS scores were notably lower on the CureJet side. Improvements in both pore and wrinkle indices were observed from baseline, with a more pronounced improvement rate on the CureJet side compared to the needle injection side. CONCLUSIONS: Needle-free injection of PN for aging skin was found to be effective in enhancing pore and wrinkle improvement, while reducing associated discomfort.

Source: Journal of Cosmetic Dermatology

DOI: 10.1111/jocd.16595

Authors: Ji Yeon Hong, Yoon Hwan Lee, Hyun‐Jo Kim, Kui Young Park

Institutions: Chung-Ang University Hospital, Chung-Ang University Healthcare System, Chung-Ang University

Language: English

Topic: Facial Rejuvenation and Surgery Techniques

Subfield: Dermatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $2,500