Work

Predictive biomarkers in colorectal adenocarcinoma – a Brazilian perspective on current and future practices

Year: 2024

Type: article

Abstract: Predictive biomarkers of response to therapy are fundamental for the personalized therapeutic management of patients with colorectal carcinoma (CRC). The main predictive biomarkers related to CRC are the mismatch repair proteins/microsatellite instability status (MMR/MSI status), RAS/RAF mutation status and HER2 status. We discuss the scenarios in which these biomarkers are used and address different aspects that may affect the evaluation of each biomarker. We also address the increasingly recognized importance of circulating tumor DNA (ctDNA) testing in the management of stage II-III CRC as well as the role of the pathologist in this setting.

Source: Surgical and Experimental Pathology

DOI: 10.1186/s42047-024-00163-3

Authors: Antonio Hugo José Fróes Marques Campos, Luciana Campi Auresco, Lidiane Vieira Marins, Paulo Henrique do Amor Divino, Jorge Sabbaga, Paulo Marcelo Hoff

Institution: D’Or Institute for Research and Education

Language: English

Topic: Colorectal Cancer Treatments and Studies

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4403203776

FWCI: 0.459

Cites: 53

Cited by: 3

Related to: 10