Perturbations in the blood metabolome up to a decade before prostate cancer diagnosis in 4387 matched case–control sets from the European Prospective Investigation into Cancer and Nutrition
Year: 2024
Type: article
Study design: Observational Study
Abstract: Measuring pre‐diagnostic blood metabolites may help identify novel risk factors for prostate cancer. Using data from 4387 matched case–control pairs from the European Prospective Investigation into Cancer and Nutrition (EPIC) study, we investigated the associations of 148 individual metabolites and three previously defined metabolite patterns with prostate cancer risk. Metabolites were measured by liquid chromatography‐mass spectrometry. Multivariable‐adjusted conditional logistic regression was used to estimate the odds ratio per standard deviation increase in log metabolite concentration and metabolite patterns (OR1SD) for prostate cancer overall, and for advanced, high‐grade, aggressive. We corrected for multiple testing using the Benjamini–Hochberg method. Overall, there were no associations between specific metabolites or metabolite patterns and overall, aggressive, or high‐grade prostate cancer that passed the multiple testing threshold ( padj <0.05). Six phosphatidylcholines (PCs) were inversely associated with advanced prostate cancer diagnosed at or within 10 years of blood collection. metabolite patterns 1 (64 PCs and three hydroxysphingomyelins) and 2 (two acylcarnitines, glutamate, ornithine, and taurine) were also inversely associated with advanced prostate cancer; when stratified by follow‐up time, these associations were observed for diagnoses at or within 10 years of recruitment (OR 1SD 0.80, 95% CI 0.66–0.96 and 0.76, 0.59–0.97, respectively) but were weaker after longer follow‐up (0.95, 0.82–1.10 and 0.85, 0.67–1.06). Pattern 3 (8 lyso PCs) was associated with prostate cancer death (0.82, 0.68–0.98). Our results suggest that the plasma metabolite profile changes in response to the presence of prostate cancer up to a decade before detection of advanced‐stage disease.
Source: International Journal of Cancer
DOI: 10.1002/ijc.35208
Authors: Zoe S. Grenville, Urwah Noor, Sabina Rinaldi, Marc J. Gunter, Pietro Ferrari, Claudia Agnoli, Pilar Amiano, Alberto Catalano, María Dolores Chirlaque, Sofia Christakoudi, Marcela Guevara, Matthias Johansson, Rudolf Kaaks, Verena Katzke, Giovanna Masala, Anja Olsen, Keren Papier, Maria‐Jose Sánchez, Matthias B. Schulze, Anne Tjønneland, Tammy Y. N. Tong, Rosario Tumino, Elisabete Weiderpass, Raul Zamora‐Ros, Timothy J. Key, Karl Smith‐Byrne, Julie A. Schmidt, Ruth C. Travis
Institutions: University of Oxford, Centre international de recherche sur le cancer, Imperial College London, Fondazione IRCCS Istituto Nazionale dei Tumori, Basque Government, Biogipuzkoa Health Research Institute, Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública, Università degli Studi del Piemonte Orientale “Amedeo Avogadro”, University of Turin, Instituto Murciano de Investigación Biosanitaria, Universidad de Murcia, Instituto de Salud Pública de Navarra, Navarre Institute of Health Research, German Cancer Research Center, Aarhus University, Universidad de Granada, Instituto de Investigación Biosanitaria de Granada, Andalusian School of Public Health, University of Potsdam, German Institute of Human Nutrition, University of Copenhagen, Associazione Iblea per la Ricerca Epidemiologica E.T.S., World Health Organization, Institut d'Investigació Biomédica de Bellvitge, Institut Català d'Oncologia, Aarhus University Hospital
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $4,840
Funders: World Health Organization, Compagnia di San Paolo, Universitetet i Tromsø, Deutsches Krebsforschungszentrum, Centres de Recerca de Catalunya, Cancer Research UK, National Institute for Health and Care Research, European Commission, Agence Nationale de la Recherche, Institut National de la Santé et de la Recherche Médicale, ZonMw, Universiteit Utrecht, Bundesministerium für Bildung und Forschung, Cancerfonden, Generalitat de Catalunya, Ministero della Salute, Vetenskapsrådet, Associazione Italiana per la Ricerca sul Cancro, Deutsche Krebshilfe, Institut Gustave-Roussy, Mutuelle Générale de l'Education Nationale, Medical Research Council, World Cancer Research Fund, Instituto de Salud Carlos III, Rijksinstituut voor Volksgezondheid en Milieu, NIHR Imperial Biomedical Research Centre, School of Public Health, Imperial College London, European Social Fund
Awards: Aetiology of type 2 diabetes and related metabolic disorders, G1102409361, G1136667113, G1171225221, G1257877605, G1691963278, G1815516331, G1851901423, G205021445, G2181795046, G2185877915, G2342228987, G254653655, G2691247007, G2714613917, G2771691379, G2802377742, G2974529408, G2978753608, G300440387, G3170692436, G3174604425, G3328679326, G3376064638, G3406693879, G3543523425, G3559681879, G365332712, G367618303, G4032711583, G4079049029, G4098851317, G4211387915, G4224896698, G423933611, G4245875310, G4289084031, G4303672817, G4378152838, G4409035895, G4417655372, G4804645139, G4844208673, G4881195352, G493358262, The EPIC-Norfolk prospective population study: biological and behavioural determinants of health and disease in an ageing population, G4968824801, G5078184151, G5116888081, G5137858745, G5253127388, G5271742736, G527520901, G5315906942, G5469230434, Etude Epidémiologique des Enfants de femmes de l'Education Nationale, G5592572481, G5618201019, G5662660744, G5748618488, G5885537923, G5910084128, G6089501056, G6132700753, G6145528938, G6156155776, G6274749655, G6280939957, G6324679927, G6376359690, G6481893073, G6487494159, G6545237157, G6555706083, G6596324812, G6672458653, G6682251940, G6739022024, G6793143258, G6835760186, G6848493935, G6852031360, G6883270616, G6896564351, G6957242214, G6972935532, G7112453972, G7256918494, G7342227767, EPIC-Oxford: benefits and risks of plant-based diets, G7453324602, G7482357016, G7537004644, G7654876629, G7656576858, G7860576566, G7987655622, G8020903098, G8139206928, G8140410841, G8187451752, G821278163, G831050355, G8353040322, G8368112200, G8377080268, G8439303526, G847199856, G8478113701, G8544555571, G8615873201, G867282411, G8695357079, G8805877516, G8817290801, G889170443, G8914830642, G8932551887, G896962615, G899966268, G928779021, G97280612
OpenAlex ID: W4403213278