Work

MICU1 and MICU2, two peas in a pod or entirely different fruits?

Year: 2024

Type: article

Abstract: Fluctuations in mitochondrial matrix Ca 2+ plays a critical role in matching energy production to cellular demand through direct effects on oxidative phosphorylation and ATP production. Disruption in mitochondrial Ca 2+ homeostasis , particularly under pathological conditions such as ischemia or heart failure, can lead to mitochondrial dysfunction, energy deficit, and eventually death of cardiomyocytes. The primary channel regulating acute mitochondrial Ca 2+ influx is the mitochondrial Ca 2+ uniporter (mtCU), which is regulated by the mitochondrial Ca 2+ uptake (MICU) proteins that were examined here.

Source: Cell Calcium

DOI: 10.1016/j.ceca.2024.102959

Authors: Jiuzhou Huo, Jeffery D. Molkentin

Institutions: Cincinnati Children's Hospital Medical Center, University of Cincinnati

Language: English

Topic: Mitochondrial Function and Pathology

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,660