Year: 2024
Type: article
Abstract: Mn(CO) 5 Br‐catalyzed reaction of 1‐(2‐pyrimidyl)indoles with 1‐sulfonyl‐2‐vinylaziridines in THF in the presence of 0.25 equiv. of NaOAc affords 2‐allylated indoles in 31 % to 100 % yields. The protocol suits for 3‐, 4‐, 5‐, 6‐, and 7‐substituted indoles and N‐(2‐pyrimidyl)pyrroles as well as various 1‐(arylsulfonyl)‐2‐vinylaziridines such as 1‐(phenylsulfonyl)‐2‐vinylaziridine, 1‐(naphthalen‐2‐ylsulfon‐yl)‐2‐vinylaziridine, and 1‐(substituted phenylsulfonyl)‐2‐vinylazirid‐ines. Functional groups including alkyl, alkoxy, halogen, CHO, COOMe, CF 3 , CN, and NO 2 groups are tolerated.
Authors: Hong Zeng, Zhong‐Xia Wang
Institution: University of Science and Technology of China
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: bronze
Award: G328709442
OpenAlex ID: W4403214312