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Figure S10 from Antiangiogenic Tyrosine Kinase Inhibitors have Differential Efficacy in Clear Cell Renal Cell Carcinoma in Bone

Year: 2024
Type: other
Abstract: TKIs’ effect on blood vessels and immune infiltrate in LVRCC67 model. A) Representative images of LVRCC67 bone tumors captured by confocal microscope; tumor cells (green, PAX8), of CD8+ cells (yellow), blood vessels (CD31, red); nuclei (blue, DAPI); dotted line, tumor edge; B) Quantification of blood vessel area, number of CD8+ cells over tumor area and CD8+ cell distribution, mean + SEM, n=3/group. P values by one-way ANOVA with Tukey’s HSD post hoc test; p < 0.01 = **. Bar, 100 µm. BV-blood vessels; V-vehicle, A-axitinib, C-cabozantinib, L-lenvatinib; Inner reg-inner region.
DOI: 10.1158/2767-9764.27187295
Authors: Stefan Maksimovic, Nina C. Boscolo, Ludovica La Posta, Sergio Barrios, Mohammad Jad Moussa, Emanuela Gentile, Pedro I. Pesquera, Wenjiao Li, Jianfeng Chen, Javier A. Gomez, Akshay Basi, Jared K. Burks, Christopher Alvarez-Breckenridge, Jianjun Gao, Matthew T. Campbell, Eleonora Dondossola
Language: English
Field: Medicine
Open Access status: gold
OpenAlex ID: W4403226825
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