Figure 5 from Antiangiogenic Tyrosine Kinase Inhibitors have Differential Efficacy in Clear Cell Renal Cell Carcinoma in Bone
Year: 2024
Type: other
Abstract: Ex vivo µCT analysis of TKIs’ effects on bone microarchitecture. A, Representative μCT micrographs of tibial metaphysis cross-sections extracted from mice treated with axitinib, cabozantinib, and lenvatinib or vehicle, Bar, 300 μm. B, Quantification of key bone histomorphometry parameters extrapolated from μCT analysis, mean ± SEM, n = 4/group. C, Impact of TKIs on TRAP+ cells in RENCA VHL− tumors in bone evaluated by IF analysis; representative images acquired at the confocal microscope (green, GFP; white, DAPI; red, TRAP) are shown; arrow, TRAP+ cells. Bar, 250 μm. P values by one-way ANOVA with Tukey honestly significant difference post hoc test; *, P < 0.05. A, axitinib; C, cabozantinib; L, lenvatinib; TRAP, tartrate-resistant acid phosphatase; V, vehicle.
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4403227648