CD38 and the mitochondrial calcium uniporter contribute to age-related hematopoietic stem cell dysfunction
Year: 2024
Type: article
Abstract: Hematopoietic stem cells (HSCs) are the multipotent progenitors of all immune cells. During aging, their regenerative capacity decreases for reasons that are not well understood. Recently, Song et al investigated the roles of two metabolic proteins in age-related HSC dysfunction: CD38 (a membrane-bound NADase) and the mitochondrial calcium uniporter that transports calcium into the mitochondrial matrix. They found that the interplay between these proteins is deranged in aged HSCs, contributing to their diminished renewal capacity. These findings implicate compromised nicotinamide adenine dinucleotide metabolism as underlying HSC dysfunction in aging.
Source: Immunometabolism
Authors: Connor S. R. Jankowski, Thomas Weichhart
Institution: Medical University of Vienna
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
Funder: Austrian Science Fund
Awards: G3634352340, G7073769033
OpenAlex ID: W4403234319