Oxidative halogenation enabled by 2-haloethanol and aqueous H2O2 under metal-free conditions
Year: 2024
Type: article
Abstract: Electrophilic halogenation reactions have been recognized as robust approaches to accessing synthetically useful organohalides. Herein, we disclose an exclusive oxidative halogenation pathway, which highlights the use of 2-haloethanol (X = Cl, Br, I) as the halogenating reagent and aqueous H 2 O 2 as the green oxidant. This method is applicable to various halogenative transformations including halogenation of olefins, alkynes and arenes, which were rarely realized by the previous oxidative halogenation systems. The obtained halogenated products can serve as versatile linchpins for further synthetic applications as demonstrated by the total synthesis of Bulgarein.
Source: Green Synthesis and Catalysis
Authors: Jingran Zhang, Haofeng Shi, Dongke Zhang, Jiaxin He, Yuli Sun, Fengxia Sun, Yunfei Du
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: diamond
OpenAlex ID: W4403243876