Letrozole induced Necrotizing Cutaneous Vasculitis: A Rare Entity
Year: 2024
Type: article
Study design: Case Report
Abstract: Cutaneous small vessel vasculitis (CSVV) could be due to varied etiologies of which drug induced CSVV is a prime cause. It commonly presents as purpura but necrotizing lesions can be an uncommon presentation of the disease. Aromatase inhibitors like letrozole are newer drugs used in the management of breast carcinoma. There have been few reports of drug induced vasculitis secondary to letrozole. Herein, we report a case presenting with multiple purpura with ulcers and hemopurulent discharge over bilateral legs after letrozole intake for breast carcinoma. Patient was diagnosed with necrotizing CSVV due to letrozole based on history and clinico-histopathological correlation. To the best of our knowledge, this is the first report of letrozole induced necrotizing CSVV from India.
Source: Clinical Dermatology Review
Authors: Liza Mohapatra, Soumya Surath Panda, Manoj Kumar Nayak, Kallolinee Samal
Institution: Institute of Medical Sciences and Sum Hospital
Language: English
Subfield: Dermatology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4403244609