Work

Phenome-wide association study in 25,639 pregnant Chinese women reveals loci associated with maternal comorbidities and child health

Year: 2024

Type: article

Study design: Observational Study

Abstract: > 0.8, revealing that 75.6% demonstrated pleiotropy and 50.9% were located in genes implicated in analogous phenotypes. Notably, we discovered 21 maternal SNPs associated with 35 neonatal phenotypes, including two SNPs associated with identical complications in both mothers and children. These findings underscore the importance of integrating ulcWGS data to enrich the discoveries derived from traditional PheWAS approaches.

Source: Cell Genomics

DOI: 10.1016/j.xgen.2024.100632

Authors: Jintao Guo, Qiwei Guo, Taoling Zhong, Chaoqun Xu, Zhongmin Xia, Hongkun Fang, Qinwei Chen, Ying Zhou, Jieqiong Xie, Dandan Jin, You Yang, Xin Wu, Huanhuan Zhu, Ailing Hour, Xin Jin, Yulin Zhou, Qiyuan Li

Institutions: Xiamen University, Weifang People's Hospital, BGI Group (China), Fu Jen Catholic University

Language: English

Topic: Genetic Associations and Epidemiology

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $8,900

Funders: Science and Technology Projects of Fujian Province, National Natural Science Foundation of China, Fujian Provincial Health Commission, National Key Research and Development Program of China

Awards: G2322800720, G2413786023, G7435513180, G8042646848, G8372819843

OpenAlex ID: W4403245877

FWCI: 0.964

Cites: 71

Cited by: 4

Related to: 10