Work

Pre-operative environmental enrichment does not yield a prophylactic effect against traumatic brain injury-induced neurobehavioral deficits

Year: 2024

Type: article

Abstract: in both pre-injury EE groups relative to the pre-injury STD groups (p < 0.05). No statistical differences were observed in cortical lesion volume among the groups. Overall, these data do not support the hypothesis as no neuroprotective effect was observed with 4 weeks of pre-operative EE and no additional benefit was achieved in the TBI group receiving both pre-and-post EE relative to the TBI group receiving only post-EE. However, the data do reinforce the consistency of post-TBI EE in producing robust neurobehavioral benefits, which further supports this paradigm as a relevant preclinical model of neurorehabilitation.

Source: Experimental Neurology

DOI: 10.1016/j.expneurol.2024.114990

Authors: Eleni H. Moschonas, Jade A. Steber, Haley E. Capeci, Hailey M. Donald, Vincent J. Vozzella, Rachel A. Bittner, Ellen M. Annas, Piper L. Rennerfeldt, Jeffrey P. Cheng, Corina O. Bondi, Anthony E. Kline

Institutions: University of Pittsburgh, Center for the Neural Basis of Cognition

Language: English

Topic: Traumatic Brain Injury Research

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,810

Funders: Brain Injury Association of America, National Institutes of Health, National Institute of Neurological Disorders and Stroke, NIH Blueprint for Neuroscience Research

Awards: Traumatic brain injury and aging: targeting the cholinergic system for deficits in sustained attention and executive function, Neurobehavioral, cognitive, and mechanistic effects of intranasally administered neural stem cells and environmental enrichment after cortical impact injury in rats, G7388935919, G9000019054, Optimizing Environmental Enrichment to Model Preclinical Neurorehabilitation

OpenAlex ID: W4403260694

FWCI: 0.519

Cites: 44

Cited by: 2

Related to: 10