Work

Detrimental effect of prenatal progesterone exposure on anxiety and depressive-like responses in adult male and female rat offspring: Role of plasma, hippocampal corticosterone and hippocampal progesterone receptors

Year: 2024

Type: article

Abstract: , s.c. during G0-G10) induces anxiogenic and depressive-like effects compared to vehicle-treated controls, which are associated with high plasma and hippocampal CORT levels and upregulated hippocampal PR in male and female adult offspring. Our results demonstrate that prenatal Pro exposure has detrimental effects on the emotional status of male and female adult offspring, which may be associated with long-term changes in hormonal homeostasis.

Source: Physiology & Behavior

DOI: 10.1016/j.physbeh.2024.114712

Authors: Zlatina Nenchovska, Milena Atanasova, Tsveta Stoynova, Gergana Toteva, Jana Tchekalarova

Institutions: Bulgarian Academy of Sciences, Institute of Neurobiology, Medical University Pleven

Language: English

Topic: Stress Responses and Cortisol

Subfield: Behavioral Neuroscience

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,270