Modelling and investigating memory immune responses in infectious disease. Application to influenza a virus and sars-cov-2 reinfections
Year: 2024
Type: article
Abstract: T-cells and memory B-cells, and by parametrising the new model with values specific to the two viruses. We first investigate the long-term dynamics of the model by identifying the virus-free steady states and studying the conditions that ensure the stability of these states. Then, we investigate the transient dynamics of this in-host model by simulating different viral reinfection times: 20 days, 60 days and 400 days after the first encounter with the pathogen. This allows us to highlight which memory immune components have the greatest impact on the viral elimination depending on the time of reinfection. Our results suggest that memory immune responses have a greater impact in the case of IAV infections compared to SARS-CoV-2 infections. Moreover, we observe that the immune response after a secondary infection is more efficient when the reinfection occurs at a shorter time.
Source: Infectious Disease Modelling
Language: English
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $1,100
OpenAlex ID: W4403262118