Work

Generation of patient-derived induced pluripotent stem cell line UJSi004-A from ultra-treatment-resistant schizophrenia

Year: 2024

Type: article

Abstract: Schizophrenia is a severe mental illness with disabling effects. Induced pluripotent stem cells (iPSCs) are generated by reprogramming peripheral blood mononuclear cells (PBMCs) from patients with ultra-treatment-resistant schizophrenia (UTRS). iPSCs have normal karyotype, express pluripotency markers and differentiate into three germ layers in vivo. This iPSC cell line carries the genetic information of the patient and is a good model for studying disease mechanisms and developing new therapies.

Source: Stem Cell Research

DOI: 10.1016/j.scr.2024.103575

Authors: Siyu Xi, Bing Xue, Yupeng Wang, Zhenghua Shan, Tianchi Song, Jing Sun, Shengying Qin

Institutions: Jiangsu University, Nantong University, Shanghai Jiao Tong University

Language: English

Topic: Pluripotent Stem Cells Research

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,320

Funders: Shanghai Science and Technology Development Foundation, National Natural Science Foundation of China, Jiangsu University, China Postdoctoral Science Foundation, Science and Technology Commission of Shanghai Municipality, National Key Research and Development Program of China, Fundamental Research Funds for the Central Universities, Fundamental Research Funds for Central Universities of the Central South University

Awards: G113104360, G1806951683, G1905207532, G368506164, G4087731263, G4623168055, G598336005

OpenAlex ID: W4403265448

FWCI: 0.353

Cites: 4

Cited by: 3

Related to: 10