Work

Ventral tegmental area amylin / calcitonin receptor signaling suppresses feeding and weight gain in female rats

Year: 2024

Type: article

Abstract: The pancreatic peptide amylin promotes negative energy balance in part through activation of amylin receptors (AmyRs) expressed in the ventral tegmental area (VTA), but studies have been limited to male rodents. We evaluated whether VTA amylin signaling governs feeding and body weight in female rats. Indeed, pharmacological VTA AmyR activation suppressed chow intake and body weight in females. Viral-mediated knockdown of VTA calcitonin receptor (GPCR of AmyR) supports the physiological relevance of VTA amylin signaling for energy balance control in females. Collectively, these data support the relevance of VTA amylin signaling for energy balance control in both sexes.

Source: Neuroscience Research

DOI: 10.1016/j.neures.2024.10.001

Authors: Tyler J. Gustafson, Lauren E. McGrath, Matthew R. Hayes, Elizabeth G. Mietlicki-Baase

Institutions: University at Buffalo, State University of New York, University of Pennsylvania

Language: English

Topic: Regulation of Appetite and Obesity

Subfield: Endocrine and Autonomic Systems

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,700